How The Immune System’s Key Organ Regenerates Itself

Credit: Freepik

With advances in cancer immunotherapy splashing across headlines, the immune system’s powerful cancer assassins—T cells—have become dinner-table conversation. But hiding in plain sight behind that “T” is the organ from which they get their name and learn their craft: the thymus.

A new study published Friday in Science Immunology identifies a molecule called BMP4 that plays a key role in the thymus’s extraordinary natural ability to recover from damage.

Credit: Fred Hutchinson Cancer Research Center

In this video, Dr. Jarrod Dudakov of Fred Hutchinson Cancer Research Center, one of the study’s leaders, talks about the importance of the thymus, the discoveries he and his colleagues have made about how it regenerates, and the team’s next steps. The researchers hope to translate their work into new therapies to improve the function of the immune system in old age and make immunotherapies more effective.

What is the thymus?

The thymus is like a boot camp for new recruits to the immune system. From their birthplace in the bone marrow, immature white blood cells go to the thymus to mature into disease-killing machines. A healthy, active thymus gets you a diverse set of different T cells, each equipped to recognize and kill a slightly different foreign target. Thus, the organ is critical for a strong immune system that’s ready to defend you from any threat.

Although the thymus is sensitive to damage from everything from infections to life stress, it is also naturally resilient. Its power to bounce back from injury, however, fades with age, and it can take a serious hit from certain aggressive cancer therapies. What if we could harness the thymus’s natural regenerative power to speed its recovery from serious injury, help it stay active with age, and make immune-harnessing drugs work better to fight cancers or infections?

What are the new findings?

BMP4, the molecule identified in the team’s new study, is only the second known driver of natural thymic regeneration. (The first one, called IL22, was discovered by the same research team in 2012.) The researchers found that BMP4 is produced by certain cells lining the inside of the organ. That molecule signals other cells of the thymus to turn on genes that promote development and repair.

Now, the team is working to figure out whether there’s a master trigger that activates the whole regeneration process—and then translate that knowledge into new therapies that help patients.

“The thymus is really a bit of a forgotten organ,” Dudakov said. “Everyone works on T cells, but not many care about where they come from. But we would argue that it’s pretty important.”

Via Fred Hutchinson Cancer Research Center

Leave a Reply

avatar
newest oldest most voted
trackback

… [Trackback]

[…] Find More here|Find More|Find More Informations here|There you will find 45799 additional Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Read More Informations here|Here you can find 88388 more Informations|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|There you can find 33826 more Infos|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|There you will find 56767 more Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Informations here|Here you will find 48638 more Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|There you will find 82877 additional Infos|Informations on that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Find More Informations here|There you will find 84021 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Read More Informations here|There you will find 62059 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Find More Infos here|Here you will find 52758 more Infos|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Find More Informations here|Here you can find 97755 more Informations|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|Here you will find 2501 more Infos|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you will find 19453 additional Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Informations here|Here you will find 70483 more Informations|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Find More Informations here|There you will find 10688 more Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|There you will find 81072 additional Infos|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Infos here|There you can find 18558 more Infos|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Read More Informations here|Here you will find 74147 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Infos here|Here you will find 93026 additional Infos|Informations on that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Read More Informations here|Here you will find 5141 additional Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Informations here|Here you will find 24646 additional Informations|Infos to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Find More Informations here|Here you can find 37914 more Informations|Informations to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Read More Informations here|There you can find 46295 more Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|Here you will find 41229 more Infos|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Infos here|Here you can find 45420 additional Infos|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Find More Informations here|There you can find 91472 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Informations here|There you can find 39850 additional Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Find More Informations here|Here you can find 30767 additional Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Informations here|Here you can find 91663 more Informations|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Informations here|There you can find 79451 more Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you will find 36902 more Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Infos here|There you can find 34473 more Infos|Infos to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Find More Informations here|There you can find 66646 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Read More Infos here|There you can find 7861 more Infos|Infos to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|Here you can find 31706 more Infos|Infos to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Find More Infos here|There you can find 34506 more Infos|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Infos here|Here you will find 59905 more Infos|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you will find 9543 additional Informations|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Read More Infos here|Here you will find 31398 more Infos|Infos to that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you can find 45816 additional Informations|Infos to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you can find 55672 more Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Read More Informations here|Here you can find 92023 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Read More Informations here|There you can find 39305 additional Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Find More Informations here|Here you can find 48323 more Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Find More Infos here|There you can find 64051 more Infos|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Find More Infos here|Here you will find 51292 more Infos|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More on|Read More|Find More Informations here|Here you can find 60355 additional Informations|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More here|Find More|Find More Infos here|There you can find 89013 additional Infos|Infos on that Topic: dailyaccord.com/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Infos here|Here you can find 52415 more Infos|Informations on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Read More here|Read More|Read More Informations here|Here you can find 38017 additional Informations|Informations to that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]

trackback

… [Trackback]

[…] Find More on|Find More|Read More Infos here|Here you will find 93427 additional Infos|Infos on that Topic: dailyaccord.com/amp/immune-systems-key-organ-regenerates/ […]